Epidermal growth factor increases the level of the cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein.

DNA synthesis was inhibited in A431 cells by epidermal growth factor (EGF) in a p21/CIP1-dependent manner [where CIP1 is cyclin-dependent kinase (CDK)-interacting protein 1]. When 1 or 10 nM EGF was added, the level of p21/CIP1 was increased to the same extent, and the protein level peaked after app...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Johannessen, L E, Knardal, S L, Madshus, I H
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1999
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220015/
https://ncbi.nlm.nih.gov/pubmed/9895307
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