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Determination of the calcium-binding sites of the C2 domain of protein kinase Calpha that are critical for its translocation to the plasma membrane.

The C2 domain is a conserved protein module present in various signal-transducing proteins. To investigate the function of the C2 domain of protein kinase Calpha (PKCalpha), we have generated a recombinant glutathione S-transferase-fused C2 domain from rat PKCalpha, PKC-C2. We found that PKC-C2 bind...

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Autors principals: Corbalán-García, S, Rodríguez-Alfaro, J A, Gómez-Fernández, J C
Format: Artigo
Idioma:Inglês
Publicat: 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220004/
https://ncbi.nlm.nih.gov/pubmed/9895296
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