Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1.

Eitemau Tebyg

• Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-zeta.
  gan: van Dijk, M, et al.
  Cyhoeddwyd: (1997)
• Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.
  gan: Cai, H, et al.
  Cyhoeddwyd: (1993)
• Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C.
  gan: Dominguez, I, et al.
  Cyhoeddwyd: (1991)
• 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation.
  gan: Van Der Hoeven, P C, et al.
  Cyhoeddwyd: (2000)
• Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids.
  gan: Limatola, C, et al.
  Cyhoeddwyd: (1994)