Loading...

Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites.

The tissue kallikrein inhibitors reported in the present work were derived by selectively replacing residues in Nalpha-substituted arginine- or phenylalanine-pNA (where pNA is p-nitroanilide), and in peptide substrates for these enzymes. Phenylacetyl-Arg-pNA was found to be an efficient inhibitor of...

Full description

Saved in:
Bibliographic Details
Main Authors: Portaro, F C, Cezari, M H, Juliano, M A, Juliano, L, Walmsley, A R, Prado, E S
Format: Artigo
Language:Inglês
Published: 1997
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218290/
https://ncbi.nlm.nih.gov/pubmed/9173877
Tags: Add Tag
No Tags, Be the first to tag this record!