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Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites.
The tissue kallikrein inhibitors reported in the present work were derived by selectively replacing residues in Nalpha-substituted arginine- or phenylalanine-pNA (where pNA is p-nitroanilide), and in peptide substrates for these enzymes. Phenylacetyl-Arg-pNA was found to be an efficient inhibitor of...
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Main Authors: | , , , , , |
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Format: | Artigo |
Language: | Inglês |
Published: |
1997
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Subjects: | |
Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1218290/ https://ncbi.nlm.nih.gov/pubmed/9173877 |
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