Evidence for activation of the tissue kallikrein-kinin system in nociceptive transmission and inflammatory responses of mice using a specific enzyme inhibitor

1. The pharmacological activity of phenylacetyl-Phe-Ser-Arg-N-(2,4-dinitrophenyl)-ethylenediamine (TKI), a tissue kallikrein specific inhibitor, was assessed using models of nociception and inflammation in mice. 2. Injection of TKI (13.6–136 μmol kg(−1), i.p. or 41–410 μmol kg(−1), s.c.) produced a...

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Detalhes bibliográficos
Main Authors: Emim, José A da S, Souccar, Caden, Castro, Maria S de A, Godinho, Rosely O, Cezari, Maria H S, Juliano, Luiz, Lapa, Antonio J
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572148/
https://ncbi.nlm.nih.gov/pubmed/10882395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703362
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