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Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites.

The tissue kallikrein inhibitors reported in the present work were derived by selectively replacing residues in Nalpha-substituted arginine- or phenylalanine-pNA (where pNA is p-nitroanilide), and in peptide substrates for these enzymes. Phenylacetyl-Arg-pNA was found to be an efficient inhibitor of...

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Detaylı Bibliyografya
Asıl Yazarlar: Portaro, F C, Cezari, M H, Juliano, M A, Juliano, L, Walmsley, A R, Prado, E S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1997
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218290/
https://ncbi.nlm.nih.gov/pubmed/9173877
Etiketler: Etiketle
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