Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction.

Several reducing sugars brought about apoptosis in isolated rat pancreatic islet cells and in the pancreatic beta-cell-derived cell line HIT. This apoptosis was characterized biochemically by inter-nucleosomal DNA cleavage and morphologically by nuclear shrinkage, chromatin condensation and apoptoti...

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Bibliografiske detaljer
Main Authors: Kaneto, H, Fujii, J, Myint, T, Miyazawa, N, Islam, K N, Kawasaki, Y, Suzuki, K, Nakamura, M, Tatsumi, H, Yamasaki, Y, Taniguchi, N
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1218007/
https://ncbi.nlm.nih.gov/pubmed/9003372
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