Ligand-induced conformational change in the human mineralocorticoid receptor occurs within its hetero-oligomeric structure.

To determine the first steps involved in the mechanism of action of aldosterone and its antagonists, we analysed the ligand-induced structural changes of the human mineralocorticoid receptor (hMR) translated in vitro. Limited chymotrypsin digestion of the receptor generated a 30 kDa fragment. Follow...

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Hlavní autoři: Couette, B, Fagart, J, Jalaguier, S, Lombes, M, Souque, A, Rafestin-Oblin, M E
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217212/
https://ncbi.nlm.nih.gov/pubmed/8615809
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