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Selection of hammerhead ribozymes for optimum cleavage of interleukin 6 mRNA.

Four GUC triplets in the coding region of the MRNA of interleukin 6 (IL-6) were examined for their suitabilty to serve as a target for hammerhead ribozome-mediated cleavage. This selection procedure was performed with the intention to downregulate IL-6 production as a potential treatment of those di...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hendrix, C, Anné, J, Joris, B, Van Aerschot, A, Herdewijn, P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217097/
https://ncbi.nlm.nih.gov/pubmed/8670082
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