Purification of 11 beta-hydroxysteroid dehydrogenase type 2 from human placenta utilizing a novel affinity labelling technique.

11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) efficiently inactivates potent glucocorticoid hormones (cortisol and corticosterone), leaving aldosterone unmetabolized. Abundant 11 beta-HSD2 activity in human placenta plays a central role in controlling fetal glucocorticoid exposure, whic...

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Autors principals: Brown, R W, Chapman, K E, Murad, P, Edwards, C R, Seckl, J R
Format: Artigo
Idioma:Inglês
Publicat: 1996
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1217009/
https://ncbi.nlm.nih.gov/pubmed/8611186
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