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p16(INK4A) Participates in a G(1) Arrest Checkpoint in Response to DNA Damage
Members of the INK4 protein family specifically inhibit cyclin-dependent kinase 4 (cdk4) and cdk6-mediated phosphorylation of the retinoblastoma susceptibility gene product (Rb). p16(INK4A), a prototypic INK4 protein, has been identified as a tumor suppressor in many human cancers. Inactivation of p...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC121508/ https://ncbi.nlm.nih.gov/pubmed/9418885 |
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