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Roles of the Mitotic Inhibitors Wee1 and Mik1 in the G(2) DNA Damage and Replication Checkpoints
The G(2) DNA damage and DNA replication checkpoints in many organisms act through the inhibitory phosphorylation of Cdc2 on tyrosine-15. This phosphorylation is catalyzed by the Wee1/Mik1 family of kinases. However, the in vivo role of these kinases in checkpoint regulation has been unclear. We show...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2001
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC86696/ https://ncbi.nlm.nih.gov/pubmed/11238887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1499-1508.2001 |
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