p16(INK4A) Participates in a G(1) Arrest Checkpoint in Response to DNA Damage

Members of the INK4 protein family specifically inhibit cyclin-dependent kinase 4 (cdk4) and cdk6-mediated phosphorylation of the retinoblastoma susceptibility gene product (Rb). p16(INK4A), a prototypic INK4 protein, has been identified as a tumor suppressor in many human cancers. Inactivation of p...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Shapiro, Geoffrey I., Edwards, Christian D., Ewen, Mark E., Rollins, Barrett J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC121508/
https://ncbi.nlm.nih.gov/pubmed/9418885
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki