The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation

AML-1B is a hematopoietic transcription factor that is functionally inactivated by multiple chromosomal translocations in human acute myeloblastic and B-cell lymphocytic leukemias. The t(8;21)(q22;q22) translocation replaces the C terminus, including the transactivation domain of AML-1B, with ETO, a...

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Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Westendorf, Jennifer J., Yamamoto, Cindy M., Lenny, Noel, Downing, James R., Selsted, Michael E., Hiebert, Scott W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1998
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC121499/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9418879/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.1.322
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