Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2α Kinases PKR and GCN2

The human double-stranded RNA-dependent protein kinase (PKR) is an important component of the interferon response to virus infection. The activation of PKR is accompanied by autophosphorylation at multiple sites, including one in the N-terminal regulatory region (Thr-258) that is required for full k...

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Main Authors: Romano, Patrick R., Garcia-Barrio, Minerva T., Zhang, Xiaolong, Wang, Qizhi, Taylor, Deborah R., Zhang, Fan, Herring, Christopher, Mathews, Michael B., Qin, Jun, Hinnebusch, Alan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC121479/
https://ncbi.nlm.nih.gov/pubmed/9528799
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