Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2α Kinases PKR and GCN2

Eitemau Tebyg

• Association of GCN1–GCN20 regulatory complex with the N-terminus of eIF2α kinase GCN2 is required for GCN2 activation
  gan: Garcia-Barrio, Minerva, et al.
  Cyhoeddwyd: (2000)
• Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR.
  gan: Taylor, D R, et al.
  Cyhoeddwyd: (1996)
• GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.
  gan: Marton, M J, et al.
  Cyhoeddwyd: (1993)
• Dimerization by Translation Initiation Factor 2 Kinase GCN2 Is Mediated by Interactions in the C-Terminal Ribosome-Binding Region and the Protein Kinase Domain
  gan: Qiu, Hongfang, et al.
  Cyhoeddwyd: (1998)
• Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells
  gan: Sattlegger, Evelyn, et al.
  Cyhoeddwyd: (2000)