Hepatitis C Virus Envelope Protein E2 Does Not Inhibit PKR by Simple Competition with Autophosphorylation Sites in the RNA-Binding Domain

Double-stranded-RNA (dsRNA)-dependent protein kinase PKR is induced by interferon and activated upon autophosphorylation. We previously identified four autophosphorylated amino acids and elucidated their participation in PKR activation. Three of these sites are in the central region of the protein,...

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Detalhes bibliográficos
Main Authors: Taylor, Deborah R., Tian, Bin, Romano, Patrick R., Hinnebusch, Alan G., Lai, Michael M. C., Mathews, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114032/
https://ncbi.nlm.nih.gov/pubmed/11152499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.3.1265-1273.2001
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