Hepatitis C Virus Envelope Protein E2 Does Not Inhibit PKR by Simple Competition with Autophosphorylation Sites in the RNA-Binding Domain

Double-stranded-RNA (dsRNA)-dependent protein kinase PKR is induced by interferon and activated upon autophosphorylation. We previously identified four autophosphorylated amino acids and elucidated their participation in PKR activation. Three of these sites are in the central region of the protein,...

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Bibliographische Detailangaben
Hauptverfasser: Taylor, Deborah R., Tian, Bin, Romano, Patrick R., Hinnebusch, Alan G., Lai, Michael M. C., Mathews, Michael B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114032/
https://ncbi.nlm.nih.gov/pubmed/11152499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.3.1265-1273.2001
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