Vaccinia Virus H3L Envelope Protein Is a Major Target of Neutralizing Antibodies in Humans and Elicits Protection against Lethal Challenge in Mice

The smallpox vaccine is the prototypic vaccine, yet the viral targets critical for vaccine-mediated protection remain unclear in humans. We have produced protein microarrays of a near-complete vaccinia proteome and used them to determine the major antigen specificities of the human humoral immune re...

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Detalhes bibliográficos
Main Authors: Davies, D. Huw, McCausland, Megan M., Valdez, Conrad, Huynh, Devan, Hernandez, Jenny E., Mu, Yunxiang, Hirst, Siddiqua, Villarreal, Luis, Felgner, Philip L., Crotty, Shane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1212608/
https://ncbi.nlm.nih.gov/pubmed/16140750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.18.11724-11733.2005
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