Redundancy and Plasticity of Neutralizing Antibody Responses Are Cornerstone Attributes of the Human Immune Response to the Smallpox Vaccine

The smallpox vaccine is widely considered the gold standard for human vaccines, yet the key antibody targets in humans remain unclear. We endeavored to identify a stereotypic, dominant, mature virion (MV) neutralizing antibody target in humans which could be used as a diagnostic serological marker o...

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Detalhes bibliográficos
Main Authors: Benhnia, Mohammed Rafii-El-Idrissi, McCausland, Megan M., Su, Hua-Poo, Singh, Kavita, Hoffmann, Julia, Davies, D. Huw, Felgner, Philip L., Head, Steven, Sette, Alessandro, Garboczi, David N., Crotty, Shane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268460/
https://ncbi.nlm.nih.gov/pubmed/18234801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02244-07
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