Sulindac metabolites inhibit epidermal growth factor receptor activation and expression

BACKGROUND: Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a decreased mortality from colorectal cancer (CRC). NSAIDs induce apoptotic cell death in colon cancer cells in vitro and inhibit growth of neoplastic colonic mucosa in vivo however, the biochemical mechanism...

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Hlavní autoři: Pangburn, Heather A, Kraus, Hanna, Ahnen, Dennis J, Rice, Pamela L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2005
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1208922/
https://ncbi.nlm.nih.gov/pubmed/16138927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3163-4-16
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