Polymorphism and Balancing Selection at Major Histocompatibility Complex Loci

Amino acid replacements in the peptide-binding region (PBR) of the functional major histocompatibility complex (Mhc) genes appear to be driven by balancing selection. Of the various types of balancing selection, we have examined a model equivalent to overdominance that confers heterozygote advantage...

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Bibliographic Details
Main Authors: Takahata, N., Satta, Y., Klein, J.
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1204941/
https://ncbi.nlm.nih.gov/pubmed/1582567
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