Crystal structure of human arginase I at 1.29-Å resolution and exploration of inhibition in the immune response

Human arginase I is a potential target for therapeutic intervention in diseases linked to compromised l-arginine homeostasis. Here, we report high-affinity binding of the reaction coordinate analogue inhibitors 2(S)-amino-6-boronohexanoic acid (ABH, K(d) = 5 nM) and S-(2-boronoethyl)-l-cysteine (BEC...

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Detalhes bibliográficos
Main Authors: Di Costanzo, Luigi, Sabio, Guadalupe, Mora, Alfonso, Rodriguez, Paulo C., Ochoa, Augusto C., Centeno, Francisco, Christianson, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201588/
https://ncbi.nlm.nih.gov/pubmed/16141327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504027102
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