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Crystal structure of human arginase I at 1.29-Å resolution and exploration of inhibition in the immune response
Human arginase I is a potential target for therapeutic intervention in diseases linked to compromised l-arginine homeostasis. Here, we report high-affinity binding of the reaction coordinate analogue inhibitors 2(S)-amino-6-boronohexanoic acid (ABH, K(d) = 5 nM) and S-(2-boronoethyl)-l-cysteine (BEC...
Tallennettuna:
| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2005
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1201588/ https://ncbi.nlm.nih.gov/pubmed/16141327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504027102 |
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