An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release.

The local control theory of excitation-contraction (EC) coupling in cardiac muscle asserts that L-type Ca(2+) current tightly controls Ca(2+) release from the sarcoplasmic reticulum (SR) via local interaction of closely apposed L-type Ca(2+) channels (LCCs) and ryanodine receptors (RyRs). These loca...

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Bibliographic Details
Main Authors: Greenstein, Joseph L, Winslow, Raimond L
Format: Artigo
Language:Inglês
Published: 2002
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201479/
https://ncbi.nlm.nih.gov/pubmed/12496068
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