Shiga Toxin 1 Induces Apoptosis in the Human Myelogenous Leukemia Cell Line THP-1 by a Caspase-8-Dependent, Tumor Necrosis Factor Receptor-Independent Mechanism

Shiga toxins (Stxs) induce apoptosis in a variety of cell types. Here, we show that Stx1 induces apoptosis in the undifferentiated myelogenous leukemia cell line THP-1 in the absence of tumor necrosis factor alpha (TNF-α) or death receptor (TNF receptor or Fas) expression. Caspase-8 and -3 inhibitor...

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Bibliographic Details
Main Authors: Lee, Sang-Yun, Cherla, Rama P., Caliskan, Isa, Tesh, Vernon L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201203/
https://ncbi.nlm.nih.gov/pubmed/16041028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.8.5115-5126.2005
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