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Tuning genetic control through promoter engineering

Gene function is typically evaluated by sampling the continuum of gene expression at only a few discrete points corresponding to gene knockout or overexpression. We argue that this characterization is incomplete and present a library of engineered promoters of varying strengths obtained through muta...

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Hlavní autoři: Alper, Hal, Fischer, Curt, Nevoigt, Elke, Stephanopoulos, Gregory
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1200280/
https://ncbi.nlm.nih.gov/pubmed/16123130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504604102
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