Direct recognition by αβ cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function

Crystallographic analysis of human Hfe has documented an overall structure similar to classical (class Ia) MHC molecules with a peptide binding groove deprived of ligand. Thus, to address the question of whether αβ T cells could recognize MHC molecules independently of bound ligands, we studied huma...

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Detalhes bibliográficos
Main Authors: Rohrlich, Pierre S., Fazilleau, Nicolas, Ginhoux, Florent, Firat, Hüseyin, Michel, Frédérique, Cochet, Madeleine, Laham, Nihay, Roth, Marie Paule, Pascolo, Steve, Nato, Faridabano, Coppin, Hélène, Charneau, Pierre, Danos, Olivier, Acuto, Oreste, Ehrlich, Rachel, Kanellopoulos, Jean, Lemonnier, François A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1200262/
https://ncbi.nlm.nih.gov/pubmed/16123136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502309102
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