The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

PTEN is an important tumor suppressor gene. Hereditary mutation of PTEN causes tumor-susceptibility diseases such as Cowden disease. We used the Cre-loxP system to generate an endothelial cell-specific mutation of Pten (Tie2CrePten) in mice. Tie2CrePten(flox/+) mice displayed enhanced tumorigenesis...

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Detalhes bibliográficos
Main Authors: Hamada, Koichi, Sasaki, Takehiko, Koni, Pandelakis A., Natsui, Miyuki, Kishimoto, Hiroyuki, Sasaki, Junko, Yajima, Nobuyuki, Horie, Yasuo, Hasegawa, Go, Naito, Makoto, Miyazaki, Jun-ichi, Suda, Toshio, Itoh, Hiroshi, Nakao, Kazuwa, Mak, Tak Wah, Nakano, Toru, Suzuki, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1199575/
https://ncbi.nlm.nih.gov/pubmed/16107612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1308805
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