A role for docosahexaenoic acid–derived neuroprotectin D1 in neural cell survival and Alzheimer disease

Deficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline. Here we report that, in cytokine-stressed human neural cells, DHA attenuates amyloid-β (Aβ) secretion, an effect accompanied by the formation of NPD1, a novel, DHA-derived 10,17S-doc...

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Detalhes bibliográficos
Main Authors: Lukiw, Walter J., Cui, Jian-Guo, Marcheselli, Victor L., Bodker, Merete, Botkjaer, Anja, Gotlinger, Katherine, Serhan, Charles N., Bazan, Nicolas G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1199531/
https://ncbi.nlm.nih.gov/pubmed/16151530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25420
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