Effects of nitroglycerin/L-cysteine on soluble guanylate cyclase: evidence for an activation/inactivation equilibrium controlled by nitric oxide binding and haem oxidation

GTN (nitroglycerin; glycerol trinitrate) causes dilation of blood vessels via activation of nitric oxide (NO)-sensitive sGC (soluble guanylate cyclase), a heterodimeric haem protein that catalyses the conversion of GTP into cGMP. Activation of sGC by GTN requires enzymatic or non-enzymatic bioactiva...

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Bibliographische Detailangaben
Hauptverfasser: Gorren, Antonius C. F., Russwurm, Michael, Kollau, Alexander, Koesling, Doris, Schmidt, Kurt, Mayer, Bernd
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2005
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1198942/
https://ncbi.nlm.nih.gov/pubmed/15907191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050565
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