Src and FAK Kinases Cooperate to Phosphorylate Paxillin Kinase Linker, Stimulate Its Focal Adhesion Localization, and Regulate Cell Spreading and Protrusiveness

The ArfGAP paxillin kinase linker (PKL)/G protein-coupled receptor kinase-interacting protein (GIT)2 has been implicated in regulating cell spreading and motility through its transient recruitment of the p21-activated kinase (PAK) to focal adhesions. The Nck-PAK-PIX-PKL protein complex is recruited...

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Hauptverfasser: Brown, Michael C., Cary, Leslie A., Jamieson, Jennifer S., Cooper, Jonathan A., Turner, Christopher E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2005
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196340/
https://ncbi.nlm.nih.gov/pubmed/16000375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-02-0131
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