Novel Mechanism of Resistance to Oxazolidinones, Macrolides, and Chloramphenicol in Ribosomal Protein L4 of the Pneumococcus

Two clinical Streptococcus pneumoniae isolates, identified as resistant to macrolides and chloramphenicol and nonsusceptible to linezolid, were found to contain 6-bp deletions in the gene encoding riboprotein L4. The gene transformed susceptible strain R6 so that it exhibited such resistance, with t...

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Autores principales: Wolter, Nicole, Smith, Anthony M., Farrell, David J., Schaffner, William, Moore, Matthew, Whitney, Cynthia G., Jorgensen, James H., Klugman, Keith P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196237/
https://ncbi.nlm.nih.gov/pubmed/16048983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3554-3557.2005
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