Cloning and Characterization of a Novel Trimethoprim-Resistant Dihydrofolate Reductase from a Nosocomial Isolate of Staphylococcus aureus CM.S2 (IMCJ1454)

A novel gene, dfrG, encoding a trimethoprim (TMP)-resistant dihydrofolate reductase (DHFR, designated S3DHFR) was cloned from a clinical isolate of methicillin-resistant Staphylococcus aureus. Escherichia coli expressing dfrG was highly resistant to TMP. Recombinant S3DHFR exhibited DHFR activity th...

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Bibliografiske detaljer
Main Authors: Sekiguchi, Jun-ichiro, Tharavichitkul, Prasit, Miyoshi-Akiyama, Tohru, Chupia, Vena, Fujino, Tomoko, Araake, Minako, Irie, Atsushi, Morita, Koji, Kuratsuji, Tadatoshi, Kirikae, Teruo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195413/
https://ncbi.nlm.nih.gov/pubmed/16127079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3948-3951.2005
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