Atazanavir Signature I50L Resistance Substitution Accounts for Unique Phenotype of Increased Susceptibility to Other Protease Inhibitors in a Variety of Human Immunodeficiency Virus Type 1 Genetic Backbones

Substitution of leucine for isoleucine at residue 50 (I50L) of human immunodeficiency virus (HIV) protease is the signature substitution for atazanavir (ATV) resistance. A unique phenotypic profile has been associated with viruses containing the I50L substitution, which produces ATV-specific resista...

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Detalhes bibliográficos
Main Authors: Weinheimer, S., Discotto, L., Friborg, J., Yang, H., Colonno, R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195397/
https://ncbi.nlm.nih.gov/pubmed/16127058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3816-3824.2005
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