Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth

Sialic acid-containing glycosphingolipids, i.e., gangliosides, constitute a major component of neuronal cells and are thought to be essential for brain function. UDP-glucose:ceramide glucosyltransferase (Ugcg) catalyzes the initial step of glycosphingolipid (GSL) biosynthesis. To gain insight into t...

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Библиографические подробности
Главные авторы: Jennemann, Richard, Sandhoff, Roger, Wang, Shijun, Kiss, Eva, Gretz, Norbert, Zuliani, Cecilia, Martin-Villalba, Ana, Jäger, Richard, Schorle, Hubert, Kenzelmann, Marc, Bonrouhi, Mahnaz, Wiegandt, Herbert, Gröne, Hermann-Josef
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2005
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1194904/
https://ncbi.nlm.nih.gov/pubmed/16109770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500893102
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