Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis

Hypothalamic neurons are main regulators of energy homeostasis. Neuronal function essentially depends on plasma membrane-located gangliosides. The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:...

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Main Authors: Nordström, Viola, Willershäuser, Monja, Herzer, Silke, Rozman, Jan, von Bohlen und Halbach, Oliver, Meldner, Sascha, Rothermel, Ulrike, Kaden, Sylvia, Roth, Fabian C., Waldeck, Clemens, Gretz, Norbert, de Angelis, Martin Hrabě, Draguhn, Andreas, Klingenspor, Martin, Gröne, Hermann-Josef, Jennemann, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595213/
https://ncbi.nlm.nih.gov/pubmed/23554574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001506
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