Suppression of Chronic Damage in Renal Allografts by Liver X Receptor (LXR) Activation: Relevant Contribution of Macrophage LXRα

Liver X receptors (LXR)-α,β regulate intracellular cholesterol homeostasis and inhibit inflammatory gene expression. We studied the effects of the LXRα,β-agonist GW3965 on acute and chronic organ damage in the F344-LEW rat kidney transplantation model. In addition, to gain LXR isoform and cell-speci...

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Detalhes bibliográficos
Main Authors: Kiss, Eva, Popovic, Zoran, Bedke, Jens, Wang, Shijun, Bonrouhi, Mahnaz, Gretz, Norbert, Stettner, Paula, Teupser, Daniel, Thiery, Joachim, Porubsky, Stefan, Adams, Judith, Gröne, Hermann-Josef
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123851/
https://ncbi.nlm.nih.gov/pubmed/21703396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.03.019
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