Human Cytomegalovirus IE1-72 Activates Ataxia Telangiectasia Mutated Kinase and a p53/p21-Mediated Growth Arrest Response

Human cytomegalovirus (HCMV) encodes several proteins that can modulate components of the cell cycle machinery. The UL123 gene product, IE1-72, binds the Rb-related, p107 protein and relieves its repression of E2F-responsive promoters; however, it is unable to induce quiescent cells to enter S phase...

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Bibliographic Details
Main Authors: Castillo, Jonathan P., Frame, Fiona M., Rogoff, Harry A., Pickering, Mary T., Yurochko, Andrew D., Kowalik, Timothy F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1193638/
https://ncbi.nlm.nih.gov/pubmed/16103197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.17.11467-11475.2005
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