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CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function

Although cytotoxic T lymphocyte antigen-4 (CTLA-4) negatively regulates T cell activation, the full range of functions mediated by this coreceptor has yet to be established. In this study, we report the surprising finding that CTLA-4 engagement by soluble antibody or CD80 potently up-regulates lymph...

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Bibliografiske detaljer
Main Authors: Schneider, Helga, Valk, Elke, da Rocha Dias, Silvy, Wei, Bin, Rudd, Christopher E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1192824/
https://ncbi.nlm.nih.gov/pubmed/16126897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505802102
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