Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1α

Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains two highly conserved oxygen-dependent degradation domains (402 ODD and 564 ODD), each of which includes a proline tha...

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Autores principales: Chan, Denise A., Sutphin, Patrick D., Yen, Shing-Erh, Giaccia, Amato J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190339/
https://ncbi.nlm.nih.gov/pubmed/16024780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6415-6426.2005
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