Deletion of the oxygen-dependent degradation domain results in impaired transcriptional activity of hypoxia-inducible factors

Hypoxia-inducible factors (HIF1α/HIF2α) are key transcription factors that promote angiogenesis. The overexpression of degradation-resistant HIF mutants is considered a promising pro-angiogenic therapeutic tool. We compared the transcriptional activity of HIF1α/HIF2α mutants that obtained their resi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Klinger, Patricia, Schietke, Ruth E, Warnecke, Christina, Swoboda, Bernd, Wiesener, Michael, Hennig, Friedrich F, Gelse, Kolja
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Landes Bioscience 2011
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265788/
https://ncbi.nlm.nih.gov/pubmed/22223045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.2.6.18619
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