Disruption of Aquaporin-11 Produces Polycystic Kidneys following Vacuolization of the Proximal Tubule

Aquaporin-11 (AQP11) has been identified with unusual pore-forming NPA (asparagine-proline-alanine) boxes, but its function is unknown. We investigated its potential contribution to the kidney. Immunohistochemistry revealed that AQP11 was localized intracellularly in the proximal tubule. When AQP11...

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Bibliographic Details
Main Authors: Morishita, Yoshiyuki, Matsuzaki, Toshiyuki, Hara-chikuma, Mariko, Andoo, Ayaka, Shimono, Mariko, Matsuki, Asako, Kobayashi, Katsuki, Ikeda, Masahiro, Yamamoto, Tadashi, Verkman, Alan, Kusano, Eiji, Ookawara, Shigeo, Takata, Kuniaki, Sasaki, Sei, Ishibashi, Kenichi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190286/
https://ncbi.nlm.nih.gov/pubmed/16107722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7770-7779.2005
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