Multiple Fates of L1 Retrotransposition Intermediates in Cultured Human Cells

LINE-1 (L1) retrotransposons comprise ∼17% of human DNA, yet little is known about L1 integration. Here, we characterized 100 retrotransposition events in HeLa cells and show that distinct DNA repair pathways can resolve L1 cDNA retrotransposition intermediates. L1 cDNA resolution can lead to variou...

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Bibliografiska uppgifter
Huvudupphovsmän: Gilbert, Nicolas, Lutz, Sheila, Morrish, Tammy A., Moran, John V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2005
Ämnen:
Chromosome Structure and Dynamics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190285/
https://ncbi.nlm.nih.gov/pubmed/16107723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7780-7795.2005
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