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Multiple Fates of L1 Retrotransposition Intermediates in Cultured Human Cells
LINE-1 (L1) retrotransposons comprise ∼17% of human DNA, yet little is known about L1 integration. Here, we characterized 100 retrotransposition events in HeLa cells and show that distinct DNA repair pathways can resolve L1 cDNA retrotransposition intermediates. L1 cDNA resolution can lead to variou...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1190285/ https://ncbi.nlm.nih.gov/pubmed/16107723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7780-7795.2005 |
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