Multiple Fates of L1 Retrotransposition Intermediates in Cultured Human Cells

LINE-1 (L1) retrotransposons comprise ∼17% of human DNA, yet little is known about L1 integration. Here, we characterized 100 retrotransposition events in HeLa cells and show that distinct DNA repair pathways can resolve L1 cDNA retrotransposition intermediates. L1 cDNA resolution can lead to variou...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gilbert, Nicolas, Lutz, Sheila, Morrish, Tammy A., Moran, John V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2005
Pynciau:
Chromosome Structure and Dynamics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190285/
https://ncbi.nlm.nih.gov/pubmed/16107723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7780-7795.2005
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