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Loss of SMEK, a Novel, Conserved Protein, Suppresses mek1 Null Cell Polarity, Chemotaxis, and Gene Expression Defects
MEK/extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase signaling is imperative for proper chemotaxis. Dictyostelium mek1(−) (MEK1 null) and erk1(−) cells exhibit severe defects in cell polarization and directional movement, but the molecules responsible for the mek1(−) and...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1190274/ https://ncbi.nlm.nih.gov/pubmed/16107728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7839-7853.2005 |
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