Loss of SMEK, a Novel, Conserved Protein, Suppresses mek1 Null Cell Polarity, Chemotaxis, and Gene Expression Defects

MEK/extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase signaling is imperative for proper chemotaxis. Dictyostelium mek1(−) (MEK1 null) and erk1(−) cells exhibit severe defects in cell polarization and directional movement, but the molecules responsible for the mek1(−) and...

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Détails bibliographiques
Auteurs principaux: Mendoza, Michelle C., Du, Fei, Iranfar, Negin, Tang, Nan, Ma, Hui, Loomis, William F., Firtel, Richard A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190274/
https://ncbi.nlm.nih.gov/pubmed/16107728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7839-7853.2005
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