Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus

The Drosophila Fused (Fu) kinase is an integral component of the Hedgehog (Hh) pathway that helps promote Hh-dependent gene transcription. Vertebrate homologues of Fu function in the Hh pathway in vitro, suggesting that Fu is evolutionarily conserved. We have generated fused (stk36) knockout mice to...

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Autori principali: Merchant, Mark, Evangelista, Marie, Luoh, Shiuh-Ming, Frantz, Gretchen D., Chalasani, Sreedevi, Carano, Richard A. D., van Hoy, Marjie, Ramirez, Julio, Ogasawara, Annie K., McFarland, Leanne M., Filvaroff, Ellen H., French, Dorothy M., de Sauvage, Frederic J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190232/
https://ncbi.nlm.nih.gov/pubmed/16055717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.16.7054-7068.2005
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