Φορτώνει......
Sequence optimization and designability of enzyme active sites
We recently found that many residues in enzyme active sites can be computationally predicted by the optimization of scoring functions based on substrate binding affinity, subject to constraints on the geometry of catalytic residues and protein stability. Here, we explore the generality of this surpr...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , |
|---|---|
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2005
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1189337/ https://ncbi.nlm.nih.gov/pubmed/16103370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505397102 |
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