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Sequence optimization and designability of enzyme active sites

We recently found that many residues in enzyme active sites can be computationally predicted by the optimization of scoring functions based on substrate binding affinity, subject to constraints on the geometry of catalytic residues and protein stability. Here, we explore the generality of this surpr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chakrabarti, Raj, Klibanov, Alexander M., Friesner, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1189337/
https://ncbi.nlm.nih.gov/pubmed/16103370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505397102
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