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Computational prediction of native protein ligand-binding and enzyme active site sequences

Recent studies reveal that the core sequences of many proteins were nearly optimized for stability by natural evolution. Surface residues, by contrast, are not so optimized, presumably because protein function is mediated through surface interactions with other molecules. Here, we sought to determin...

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Sonraí Bibleagrafaíochta
Main Authors: Chakrabarti, Raj, Klibanov, Alexander M., Friesner, Richard A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177389/
https://ncbi.nlm.nih.gov/pubmed/15998733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504023102
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