An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation

The identity of the cellular mechanisms through which nitroglycerin (glyceryl trinitrate, GTN) elicits nitric oxide (NO)-based signaling to dilate blood vessels remains one of the longest standing foci of investigation and sources of controversy in cardiovascular biology. Recent evidence suggests an...

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Autori principali: Chen, Zhiqiang, Foster, Matthew W., Zhang, Jian, Mao, Lan, Rockman, Howard A., Kawamoto, Toshihiro, Kitagawa, Kyoko, Nakayama, Keiichi I., Hess, Douglas T., Stamler, Jonathan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1189320/
https://ncbi.nlm.nih.gov/pubmed/16103363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503723102
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