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Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo
RNA interference (RNAi) has become an invaluable tool for functional genomics. A critical use of this tool depends on an understanding of the factors that determine the specificity and activity of the active agent, small interfering RNA (siRNA). Several studies have concluded that tolerance of mutat...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1188085/ https://ncbi.nlm.nih.gov/pubmed/16113241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki785 |
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